I believe that Photoshop is not specifically designed for creating web design layouts. The rise in popularity of minimalist design styles like iOS, Metro, etc., has strengthened this belief. It's like using a jackhammer to hammer nails.

Is there a simpler and faster solution for efficiently preparing a design layout, with the convenience of easy integration? A solution that enables effortless distribution of elements over images, automatic selection of formats with minimal file size, quick creation and addition of effects, while minimizing unnecessary functions?

And all of this specifically for Mac OS.

Yes, there are alternative design tools specifically designed for creating web design layouts on Mac OS. One popular option is Sketch, a vector-based design tool that provides a simpler and faster workflow for web and interface design. Sketch offers a range of features tailored to web design needs, such as easy integration with prototyping tools, the ability to distribute elements over images, and automatic selection of optimized image formats with minimal file size.

Additionally, tools like Figma and Adobe XD are also widely used in the web design community. These tools offer similar functionality to Sketch and provide intuitive interfaces for a seamless design experience. These alternatives aim to streamline the design process by focusing on essential web design functions while minimizing unnecessary features.

In addition to Sketch, Figma, and Adobe XD, there are a few more design tools that you might find useful for creating web design layouts on Mac OS:

1. InVision Studio: It's a powerful design and prototyping tool that allows you to create interactive web design layouts with ease. It offers advanced animation and collaboration features, making it a popular choice among designers.

2. Axure RP: This tool is primarily focused on creating interactive wireframes, prototypes, and specifications. It has robust functionality for designing complex web interfaces and offers features like conditional logic, dynamic content, and adaptive views.

3. Webflow: Webflow combines design and development into one platform, allowing you to visually design and build responsive websites without coding. It offers a range of web design features, including a powerful visual editor, pre-built components, and hosting capabilities.

4. Affinity Designer: While not exclusively for web design, Affinity Designer is a professional vector graphics editor that provides a wide range of tools and features relevant to web design. It is known for its speed and performance and offers precise control over vector artwork.

 few more design tools for Mac OS that you can consider:

1. Adobe Illustrator: Although not specifically designed for web design layouts, Adobe Illustrator is a powerful vector graphics editor that offers a vast array of tools and features. It's widely used by designers for creating web design elements and icons.

2. Gravit Designer: This free design tool provides a cross-platform solution for creating vector-based illustrations, UI designs, and web graphics. It offers a wide range of features, including layers, symbols, and export options.

3. Canva: Canva is a popular web-based design tool that offers a user-friendly interface and a wide variety of templates for web design layouts. It allows you to create beautiful designs without the need for advanced design skills.

4. Marvel: Marvel is a prototyping tool that simplifies the process of designing and testing interactive web prototypes. It offers an intuitive interface, seamless integration with design tools, and collaboration features.

These tools provide additional choices for web designers on macOS, offering different features, workflows, and levels of complexity. Depending on your specific needs and preferences, you can explore these options to find the one that best suits your requirements.

There are various recommendations for Photoshop alternatives, such as Webflow.com, Macaw.co, and Pinegrow, but the truly radical choice is Sublime Text

Webflow provides the solution you're seeking. In addition, I've been utilizing an illustrator extensively in my recent project.

The latest versions of Quark have the capability to save web pages with CSS. This feature seems promising for exporting layouts in HTML5, although I haven't personally tested it yet.

Figma might just be the future of web design, and it's free for solo designers. This browser-based powerhouse offers real-time collaboration, vector network, and component-based workflow. Sure, it's not native Mac, but the performance is solid, and the features are top-notch.
Plus, no more fighting with pesky .psd files – just share a link and call it a day.